Rosi Braidotti's contribution to the Deleuze Studies Conference 2016 held in Rome (University of Roma Tre, 11–13 July), later transcribed and then revised by the author, points firmly to the current need for an affirmative thinking approach, actively standing to the present, while assessing its becoming and imagining new configurations. Saying yes to the world, being worthy of it, does not entail passive acceptance but rather the activation of transformative and critical thinking. To this aim, Braidotti looks at Deleuze as well as at feminist theory. The ontology of immanence turns into a materialist, collective, vital, embodied and relational ethics.