With the 2030 Agenda, the development paradigm has shifted towards global sustainable development, but modes of cooperation between actors in the Global North and South still cling to traditional patterns of cooperation, reproducing antiquated knowledge hierarchies. Departing from technical cooperation, transnational research cooperation may be a more equitable mode of cooperation with the potential of developing innovative solutions for sustainable development. Yet, its potential is not fully realised. Science policies on the national level and global governance mechanisms need to set a beneficial framework, ensuring that expectations of partnerships and outcomes for global sustainable development can be met. The current incoherence of national science and development cooperation policies may be aggravated by existing gaps in global governance mechanisms in view of sustainability-oriented transnational research cooperation.