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100 Years of Human Chorionic Gonadotropin
hCG anecdote 1 extracting C5 and creating the antibody B152—the birth of hyperglycosylated hCG
edited_book
Author(s):
Laurence A. Cole
Publication date
(Print):
2020
Publisher:
Elsevier
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Author and book information
Book Chapter
Publication date (Print):
2020
Pages
: 3-4
DOI:
10.1016/B978-0-12-820050-6.00001-1
SO-VID:
58fe4f4a-539d-4ab2-8c60-02566878c9e0
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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Book chapters
pp. iii
Front Matter
pp. iv
Copyright
pp. xix
About the editors
pp. xv
Contributors
pp. xxiii
Foreword—100 Years of hCG
pp. xxv
Acknowledgments
pp. 3
hCG anecdote 1 extracting C5 and creating the antibody B152—the birth of hyperglycosylated hCG
pp. 5
Evolutionary, structural, and physiological differences between hCG and LH
pp. 19
hCG and human evolution—The human master molecule
pp. 31
Human chorionic gonadotropin
pp. 45
Molecular modeling of human chorionic gonadotropin glycosylation, nicking, and carboxyl terminal extension
pp. 65
Why hCG is glycosylated
pp. 73
Detecting hCG that is not there—Anecdote
pp. 75
Detection and quantification of hCG and its isoforms with MALDI-ToF mass spectrometry
pp. 87
Pregnancy failures and false-positive hCG tests
pp. 107
The home pregnancy test
pp. 123
Human chorionic gonadotropin determination using mass spectrometry
pp. 139
hCGβcf as a quality control marker for urine mass spectrometry analysis
pp. 151
How hCG was used as tool to study LH action
pp. 153
The role of hCG in endometrial receptivity and embryo implantation
pp. 167
Qualitative analysis of hCG variants and glycoforms in urine, using matrix-assisted laser desorption ionization time-of-flight mass spectrometry
pp. 181
Phenotypic characterization of transgenic mouse models overproducing hCG
pp. 193
Role of human chorionic gonadotropin in reproductive medicine
pp. 199
Pregnancy hCG
pp. 209
My journey with human chorionic gonadotropin
pp. 227
Evaluation of delivery systems for active immunization with synthetic peptides of hCG as a fertility control method
pp. 253
Negative control—how hCG, and a failed experiment, changed my life
pp. 255
Human chorionic gonadotropin in cancer—where are we?
pp. 261
LH/hCG receptor–independent activities of hCG and hCGβ
pp. 269
The role of the free β-subunit of human chorionic gonadotropin in human malignancy
pp. 283
hCG and gestational trophoblastic diseases
pp. 293
Immunotherapy of advanced stage, invariably drug-resistant cancers expressing ectopically hCG
pp. 301
A potential cure for cancer
pp. 315
Where has hCG research been? What is hCG research doing? Which direction will it go in the future?
pp. 323
Index
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