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Kommunikation durch Neuronen

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Author(s): Kurt Jungermann , Hanns Möhler

Publication date (Print): 1980

Publisher: Springer Berlin Heidelberg

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Benzodiazepine receptor: demonstration in the central nervous system.

Junpei T. Okada, H. Mohler (1977)

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.