Between the American Revolution and the US Civil War, the geography of slavery and freedom in North America changed radically. In some respects, this was an age of emancipation. The northern US, Canada, and Mexico all abolished slavery in this period, and the transatlantic slave trade itself was abolished in 1808. In the southern US, however, slavery underwent an enormous expansion—from the Atlantic seaboard to Texas—mainly as a result of the successful introduction of cotton in the newly acquired lands of the southern interior. In the age of the “second slavery,” southern slavery grew at an unprecedented rate and became characterized by a number of unique features, including a slave population that was almost entirely born in slavery; the development of a massive internal slave trade that wrought havoc on slave communities; the dominance of cotton plantation agriculture in the lives of most enslaved people; the adaptation of slavery to urban settings; the curtailment of manumissions; and the rise of a continent-wide refugee crisis, as freedom seekers fled to parts of the continent where slavery had been abolished. This chapter will explore the institution of slavery in one of its most well-known contexts.