Structural insights into the evolutionary simplification of human ClpP activators.

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Abstract

In this issue of Structure, Mabanglo et al. characterize five ClpP agonists termed TRs. The co-crystal structures reveal more robust shape and charge complementarities than the anti-cancer agent ONC201. These novel compounds are of potential therapeutic interest because they enhance ClpP proteolytic activity and have an inhibitory effect on tumor cell growth.

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Journal

Journal ID (iso-abbrev): Structure

Title: Structure (London, England : 1993)

Publisher: Elsevier BV

ISSN (Electronic): 1878-4186

ISSN (Print): 0969-2126

Publication date (Electronic): Feb 02 2023

Volume: 31

Issue: 2

Affiliations

[1 ] State Key Laboratory of Drug Research, Centre for Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.

[2 ] State Key Laboratory of Drug Research, Centre for Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: yangcg@simm.ac.cn.

Article

Publisher Item ID: S0969-2126(23)00004-7

DOI: 10.1016/j.str.2023.01.002

PubMed ID: 36736297

SO-VID: 12f90e4f-5bdf-4f76-8e6c-433b4ff83f61

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