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      Heatstroke predictions by machine learning, weather information, and an all-population registry for 12-hour heatstroke alerts

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          Abstract

          This study aims to develop and validate prediction models for the number of all heatstroke cases, and heatstrokes of hospital admission and death cases per city per 12 h, using multiple weather information and a population-based database for heatstroke patients in 16 Japanese cities (corresponding to around a 10,000,000 population size). In the testing dataset, mean absolute percentage error of generalized linear models with wet bulb globe temperature as the only predictor and the optimal models, respectively, are 43.0% and 14.8% for spikes in the number of all heatstroke cases, and 37.7% and 10.6% for spikes in the number of heatstrokes of hospital admission and death cases. The optimal models predict the spikes in the number of heatstrokes well by machine learning methods including non-linear multivariable predictors and/or under-sampling and bagging. Here, we develop prediction models whose predictive performances are high enough to be implemented in public health settings.

          Abstract

          In the context of climate change, heatstroke is expected to become an increasingly relevant public health concern. Here, the authors develop and validate prediction models for the number of all heatstroke cases in different cities in Japan.

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          Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

          Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.
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            Building Predictive Models inRUsing thecaretPackage

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              Heat Stroke

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                Author and article information

                Contributors
                knishimu@ncvc.go.jp
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                28 July 2021
                28 July 2021
                2021
                : 12
                : 4575
                Affiliations
                [1 ]GRID grid.410796.d, ISNI 0000 0004 0378 8307, Department of Preventive Medicine and Epidemiology, , National Cerebral and Cardiovascular Center, ; Suita, Osaka Japan
                [2 ]GRID grid.412013.5, ISNI 0000 0001 2185 3035, Department of Civil, Environmental and Applied Systems Engineering, Faculty of Environmental and Urban Engineering, , Kansai University, ; Suita, Osaka Japan
                [3 ]GRID grid.410796.d, ISNI 0000 0004 0378 8307, Department of Cardiovascular Medicine, , National Cerebral and Cardiovascular Center, ; Suita, Osaka Japan
                [4 ]GRID grid.410796.d, ISNI 0000 0004 0378 8307, Director General, National Cerebral and Cardiovascular Center Hospital, ; Suita, Osaka Japan
                [5 ]GRID grid.140139.e, ISNI 0000 0001 0746 5933, Health and Environmental Risk Division, , National Institute for Environmental Studies, ; Tsukuba, Ibaraki Japan
                [6 ]GRID grid.140139.e, ISNI 0000 0001 0746 5933, Earth System Division, , National Institute for Environmental Studies, ; Tsukuba, Ibaraki Japan
                [7 ]GRID grid.26999.3d, ISNI 0000 0001 2151 536X, Department of Urban Engineering, School of Engineering, , The University of Tokyo, ; Tokyo, Japan
                [8 ]GRID grid.26091.3c, ISNI 0000 0004 1936 9959, Graduate School of System Design and Management, , Keio University, ; Yokohama, Kanagawa Japan
                Author information
                http://orcid.org/0000-0001-9596-9188
                http://orcid.org/0000-0001-8741-5345
                http://orcid.org/0000-0001-5111-8912
                http://orcid.org/0000-0002-0639-0949
                Article
                24823
                10.1038/s41467-021-24823-0
                8319225
                34321480
                1f649e93-d912-45cc-baba-31362382a96c
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 1 February 2021
                : 8 July 2021
                Funding
                Funded by: Environment Research and Technology Development Fund (JPMEERF20191005) of the Environmental Restoration and Conservation Agency of Japan
                Funded by: Environment Research and Technology Development Fund (JPMEERF20191005) of the Environmental Restoration and Conservation Agency of Japan. Intramural Research Fund of Cardiovascular Diseases of the National Cerebral and Cardiovascular Center (30-6-15)
                Categories
                Article
                Custom metadata
                © The Author(s) 2021

                Uncategorized
                machine learning,environmental health,public health
                Uncategorized
                machine learning, environmental health, public health

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