Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d20681100e125">Butyrylcholinesterase (BChE) is considered a promising drug target for the treatment of moderate to severe Alzheimer's disease (AD). Here, we review medicinal-chemistry strategies that are currently available for the discovery of selective BChE inhibitors. </p>

Related collections

Author and article information

Journal

Title: Drug Discovery Today

Abbreviated Title: Drug Discovery Today

Publisher: Elsevier BV

ISSN (Print): 13596446

Publication date Created: November 2018

Publication date (Print): November 2018

Article

DOI: 10.1016/j.drudis.2018.11.012

PubMed ID: 30503804

SO-VID: 20e4a845-2340-48c6-823e-4c9955e1c47e

License:

https://www.elsevier.com/tdm/userlicense/1.0/

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.