TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity

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Abstract

Transient receptor potential (TRP) ion channels serve as sensors for variations in ambient temperature, modulating both thermoregulation and temperature responsive cellular processes. Among these, the vanilloid TRP subfamily (TRPV) comprises six members and at least four of these members (TRPV1-TRPV4) have been associated with thermal sensation. TRPV2 has been described as a sensor for noxious heat, but subsequent studies have unveiled a more complex role for TRPV2 beyond temperature perception. This comprehensive review aims to elucidate the intricate thermosensitivity of TRPV2 by synthesizing current knowledge on its biophysical properties, expression pattern and known physiological functions associated with thermosensation.

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Most cited references 77

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.

Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen (2005)

Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions. Furthermore, blood-brain barrier disruption provoked immediate and focal activation of microglia, switching their behavior from patroling to shielding of the injured site. Microglia thus are busy and vigilant housekeepers in the adult brain.

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Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

M. J. Caterina, A. Leffler, A. Malmberg … (2000)

The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli. VR1-/- mice showed normal responses to noxious mechanical stimuli but exhibited no vanilloid-evoked pain behavior, were impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.

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Microglia in Physiology and Disease.

H W G M Boddeke, Susanne Wolf, Helmut Kettenmann (2017)

As the immune-competent cells of the brain, microglia play an increasingly important role in maintaining normal brain function. They invade the brain early in development, transform into a highly ramified phenotype, and constantly screen their environment. Microglia are activated by any type of pathologic event or change in brain homeostasis. This activation process is highly diverse and depends on the context and type of the stressor or pathology. Microglia can strongly influence the pathologic outcome or response to a stressor due to the release of a plethora of substances, including cytokines, chemokines, and growth factors. They are the professional phagocytes of the brain and help orchestrate the immunological response by interacting with infiltrating immune cells. We describe here the diversity of microglia phenotypes and their responses in health, aging, and disease. We also review the current literature about the impact of lifestyle on microglia responses and discuss treatment options that modulate microglial phenotypes.

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Author and article information

Contributors

Andreas Leffler:

ORCID: http://orcid.org/0000-0003-1121-6387

leffler.andreas@mh-hannover.de

Journal

Journal ID (nlm-ta): J Physiol Sci

Journal ID (iso-abbrev): J Physiol Sci

Title: The Journal of Physiological Sciences : JPS

Publisher: BioMed Central (London )

ISSN (Print): 1880-6546

ISSN (Electronic): 1880-6562

Publication date (Electronic): 16 September 2024

Publication date PMC-release: 16 September 2024

Publication date Collection: 2024

Volume: 74

Electronic Location Identifier: 42

Affiliations

Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, ( https://ror.org/00f2yqf98) Carl-Neuberg Strasse 1, 30625 Hannover, Germany

Author information

Andreas Leffler http://orcid.org/0000-0003-1121-6387

Article

Publisher ID: 936

DOI: 10.1186/s12576-024-00936-1

PMC ID: 11403965

PubMed ID: 39285320

SO-VID: 25161eba-0d3d-4165-9138-d94ba5536bdc

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 16 June 2024

Date accepted : 31 August 2024

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ScienceOpen disciplines: Anatomy & Physiology

Keywords: ion channel,thermosensitivity,heat,trpv2,physiology

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ScienceOpen disciplines: Anatomy & Physiology

Keywords: ion channel, thermosensitivity, heat, trpv2, physiology

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TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity

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Most cited references 77

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.

Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

Microglia in Physiology and Disease.

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