Impact of Reconstruction Route on Postoperative Morbidity After Esophagectomy: Analysis of Esophagectomies in the Japanese National Clinical Database

Abstract

Background

Esophagectomy followed by gastric conduit reconstruction is a standard surgical procedure for esophageal cancer. However, there is no evidence of the superiority or inferiority of the posterior mediastinal (PM) versus the retrosternal (RS) reconstruction route with regard to short‐term outcomes after esophagectomy. We aimed to elucidate whether the reconstruction route can affect the short‐term outcomes after esophagectomy followed by gastric conduit reconstruction.

Methods

We reviewed the clinical data of patients who underwent esophagectomy between 2016 and 2018 from the Japanese National Clinical Database. This study included 9786 patients who underwent gastric conduit reconstruction through the PM or RS route with cervical anastomosis.

Results

Of the 9786 patients analyzed, 3478 and 6308 underwent gastric conduit reconstruction thorough the PM and RS routes, respectively. The incidence of anastomotic leak and surgical site infection (SSI) was significantly lower in the PM group than in the RS group (11.7% vs 13.8%, P = .005 and 8.4% vs 14.9%, P < .001, respectively), while the incidence of pneumonia was higher in the PM group (13.7% vs 12.2%, P = .040). Generalized estimating equation logistic regression analysis revealed a higher risk of anastomotic leak and SSI (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.15–1.51; P < .001 and OR, 2.06; 95% CI, 1.78–2.38; P < .001, respectively) and a lower risk of pneumonia (OR, 0.86; 95% CI, 0.75–0.98; P = .028) in the RS group than in the PM group.

Conclusion

The findings of this study will help surgeons to design the reconstruction route following esophagectomy.

Abstract

We reviewed the clinical data of patients who underwent esophagectomy from the Japanese National Clinical Database to elucidate whether the reconstruction route can affect the short‐term outcomes. The retrosternal route was identified as a risk factor for anastomotic leak and surgical site infection, and the posterior mediastinal (PM) route for pneumonia.