Escape rooms are a relatively new cultural phenomenon, attracting a wide range of audiences to test their puzzle-solving skills. While this format has been trialled in an educational context, there has been little exploration of it as a tool for engagement. We ran a STEM-based escape room, open to the public, over five days at a science centre in Malta. This was an exploratory exercise to determine whether escape rooms could be successful in an informal science engagement context. Over seventy players attempted the game and completed our evaluation. Our results suggest that escape rooms can be used in engagement contexts as they provide a positive experience that encourages future interactions with science. They may also draw audiences not normally interested in science and help them engage with scientific content in a more accessible manner. Interestingly, players were able to persist in engaging with content they found difficult while still finding it enjoyable, which has implications for the science communication of complex topics. Finally, players perceived that they were able to learn science through the escape room, which may increase their self-efficacy.