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      Carcinossarcoma tireoidiano em um cão Translated title: Thyroid carcinosarcoma in a dog

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          Abstract

          Uma cadela de dois anos de idade, sem raça definida, apresentou disfagia e aumento de volume da região cervical ventral, correspondendo à região tireoidiana. Duas massas localizadas nessa região foram removidas cirurgicamente. O cão morreu poucos dias após a cirurgia e não foi necropsiado. O diagnóstico de carcinossarcoma de tireóide baseou-se na presença de componentes neoplásicos epiteliais e mesenquimais malignos, os quais foram confirmados pela reação imunoistoquímica positiva para citoqueratina e vimentina, respectivamente. A origem tireoidiana foi confirmada pela imunomarcação positiva para tireoglobulina nas células epiteliais foliculares e no colóide. Este é um neoplasma raramente diagnosticado em cães.

          Translated abstract

          A two year-old female mongrel dog was presented with dysphagia and focal swelling at the thyroid region. Two masses were surgically removed from that site. The dog died a few days after surgery and it was not submitted to necropsy. The diagnosis of thyroid carcinosarcoma was based on malignant epithelial and mesenchymal cell components of the neoplasm and confirmed by immunohistochemistry for cytokeratin and vimentin, respectively. The thyroid origin was confirmed based on the positive immunostaining for thyroglobulin on the follicular epithelial cells and colloid. This is a neoplasm rarely diagnosed in dogs.

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          Most cited references14

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          Thyroid carcinosarcoma in a dog.

          An adult male mixed breed dog developed pain, on swallowing, that lasted for 1 week. Physical exam and radiographs revealed a subcutaneous mass in the cervical area and three metastatic nodules in the lung. The cervical mass was surgically removed and fixed in 10% buffered formalin. Histopathologic diagnosis was carcinosarcoma supported by positive immunohistochemistry (IHC) results for cytokeratin and vimentin. IHC for thyroglobulin proved that the tissue of origin was the thyroid gland. This is the fifth canine case of thyroid carcinosarcoma to be documented, but the first one to be confirmed by specific cell markers. It is an extremely rare neoplasm that also occurs in people.
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            Management of thyroid carcinosarcoma

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              On the occurrence of true mixed carcinomatous and sarcomatous tumors (sarcocarcinoma) with report of mixed carcinoma-chondrosarcoma of the thyroid of a dog

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                Author and article information

                Journal
                cr
                Ciência Rural
                Cienc. Rural
                Universidade Federal de Santa Maria (Santa Maria, RS, Brazil )
                0103-8478
                1678-4596
                August 2007
                : 37
                : 4
                : 1188-1191
                Affiliations
                [01] Santa Maria RS orgnameUniversidade Federal de Santa Maria orgdiv1Centro de Ciências Rurais orgdiv2Programa de Pós-graduação em Medicina Veterinária Brasil
                [02] Santa Maria RS orgnameUniversidade Federal de Santa Maria Brasil
                [03] Santa Maria RS orgnameUniversidade Federal de Santa Maria orgdiv1Centro de Ciências da Saúde orgdiv2Departamento de Patologia Brasil
                Article
                S0103-84782007000400048 S0103-8478(07)03700448
                4e477a24-a659-4c11-9a46-6a1a2bb7630f

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 16 September 2006
                : 13 December 2006
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 14, Pages: 4
                Product

                SciELO Brazil

                Categories
                Patologia

                neoplasmas da tireóide,immunohistochemistry,veterinary pathology,diseases of dogs,malignant mixed tumor,thyroid neoplasms,patologia veterinária,imunoistoquímica,doenças de cães,tumor misto maligno

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