A glucocorticoid-receptor agonist ameliorates bleomycin-induced alveolar simplification in newborn rats.

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Abstract

Glucocorticoids (GCs) are highly effective yet problematic agents against bronchopulmonary dysplasia (BPD). The dimeric trans-activation of GCs induces unfavorable effects, while monomeric trans-repression suppresses inflammation-related genes. Recently, non-steroidal-selective glucocorticoid-receptor agonists and modulators (SEGRAMs) with only the trans-repressive action have been designed.

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Journal

Journal ID (iso-abbrev): Pediatr Res

Title: Pediatric research

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1530-0447

ISSN (Print): 0031-3998

Publication date (Electronic): May 2023

Volume: 93

Issue: 6

Affiliations

[1 ] Division of Neonatology, Department of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.

[2 ] Division of Neonatology, Department of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan. tohru.ogihara@ompu.ac.jp.

[3 ] Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.

[4 ] Department of Medical Statistics, Research & Development Center, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.

Article

Publisher Item ID: 10.1038/s41390-022-02257-8

DOI: 10.1038/s41390-022-02257-8

PubMed ID: 36068343

SO-VID: 58879e8e-f287-467d-beb1-9ab169dd5d9b

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