Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes.

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Abstract

Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM II.

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Author and article information

Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Sep 2014

Volume: 34

Issue: 9

Affiliations

[1 ] From the Experimental Cardiovascular Research Unit (A.E., I.G., H.G., M.N., P.D., E.B., A.P., M.N., H.B., J.N.) and Department of Clinical Sciences (I.G.M., M.O.-M., O.M.), Clinical Research Center, Clinical Sciences, Lund University, Malmö, Sweden; and Department of Cardiology-Coronary Diseases, Skåne University Hospital, Malmö, Sweden (A.E., I.G., H.G., A.P., M.N.). Andreas.edsfeldt@med.lu.se.

[2 ] From the Experimental Cardiovascular Research Unit (A.E., I.G., H.G., M.N., P.D., E.B., A.P., M.N., H.B., J.N.) and Department of Clinical Sciences (I.G.M., M.O.-M., O.M.), Clinical Research Center, Clinical Sciences, Lund University, Malmö, Sweden; and Department of Cardiology-Coronary Diseases, Skåne University Hospital, Malmö, Sweden (A.E., I.G., H.G., A.P., M.N.).

Article

Publisher Item ID: ATVBAHA.114.303414

DOI: 10.1161/ATVBAHA.114.303414

PubMed ID: 25035341

SO-VID: 6b93a573-876d-45a4-b4f5-1999c21adb93

History

Keywords: extracellular matrix,atherosclerosis,diabetes mellitus,inflammation,stroke

Data availability:

Keywords: extracellular matrix, atherosclerosis, diabetes mellitus, inflammation, stroke

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