Minimally invasive image-guided therapy for inoperable hepatocellular carcinoma: What is the evidence today? – ScienceOpen
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      Minimally invasive image-guided therapy for inoperable hepatocellular carcinoma: What is the evidence today?

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          Abstract

          Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver that accounts for an important health problem worldwide. Only 10–15% of HCC patients are suitable candidates for hepatic resection and liver transplantation due to the advanced stage of the disease at time of diagnosis and shortage of donors. Therefore, several minimally invasive image-guided therapies for locoregional treatment have been developed. Tumor ablative techniques are either based on thermal tumor destruction, as in radiofrequency ablation, cryoablation, microwave ablation, laser ablation and high-intensity focused ultrasound, or chemical tumor destruction, as in percutaneous ethanol injection. Image-guided catheter-based techniques rely on intra-arterial delivery of embolic, chemoembolic or radioembolic agents. These minimally invasive image-guided therapies have revolutionized the management of inoperable HCC. This review provides a description of all minimally invasive image-guided therapies currently available, an up-to-date overview of the scientific evidence for their clinical use, and thoughts for future directions.

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          Most cited references128

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          Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver.

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            Prognostic prediction and treatment strategy in hepatocellular carcinoma.

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                Author and article information

                Contributors
                +31-88-7556689 , +31-30-28019098 , m.a.vandenbosch@umcutrecht.nl
                Journal
                Insights Imaging
                Insights Imaging
                Insights into Imaging
                Springer-Verlag (Berlin/Heidelberg )
                1869-4101
                1 June 2010
                1 June 2010
                July 2010
                : 1
                : 3
                : 167-181
                Affiliations
                [1 ]Department of Radiology, University Medical Center Utrecht, Room E.01.132, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
                [2 ]Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
                [3 ]Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
                [4 ]Department of Radiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
                Article
                27
                10.1007/s13244-010-0027-6
                3288853
                23100194
                717e61bd-9914-4e58-9578-41e7a5d428fc
                © The Author(s) 2010
                History
                : 24 February 2010
                : 23 May 2010
                : 28 May 2010
                Categories
                Review
                Custom metadata
                © European Society of Radiology 2010

                Radiology & Imaging
                embolization,intra-arterial infusion,ablation techniques,liver cancer,hepatocellular carcinoma

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