Taro Kominami:
ORCID: https://orcid.org/0009-0000-0612-2576
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Tien-En Tan: Role: Data curationRole: Formal analysisRole: Investigation
Hiroaki Ushida: Role: Data curationRole: InvestigationRole: Methodology
Kanika Jain: Role: Data curationRole: Investigation
Kensuke Goto: Role: Data curationRole: Investigation
Yasmin M. Bylstra: Role: Data curationRole: InvestigationRole: Methodology
Ai Fujita Sajiki:
ORCID: https://orcid.org/0000-0001-7474-9194
Role: Data curationRole: Formal analysisRole: MethodologyRole: Writing – review &
editing
Ranjana S. Mathur: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Junya Ota:
ORCID: https://orcid.org/0009-0007-7124-7595
Role: Data curationRole: Writing – review & editing
Weng Khong Lim: Role: Data curationRole: InvestigationRole: Writing – review & editing
Koji M Nishiguchi: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Beau J. Fenner:
ORCID: https://orcid.org/0000-0002-5356-7604
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Tatsuya Inoue: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
19
February
2025
Publication date Collection: 2025
Volume: 20
Issue: 2
Electronic Location Identifier: e0318857
Affiliations
[1
]
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya,
Aichi, Japan
[2
]
Singapore National Eye Centre, Singapore Eye Research Institute, and Ophthalmology
and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore, Singapore
[3
]
Genome Institute of Singapore, Singapore, Singapore
[4
]
Institute for Precision Medicine, SingHealth Duke-NUS Graduate Medical School, Singapore, Singapore
[5
]
Division for Advanced Medical Research, Center for Research of Laboratory Animals
and Medical Research Engineering, Nagoya University Graduate School of Medicine, Nagoya,
Aichi, Japan
Yokohama City University, JAPAN
Author notes
Competing Interests: The authors have declared that no competing interests exist.
☯ These authors contributed equally to this work as first authors.
Author information
Article
Publisher ID:
PONE-D-24-48432
DOI: 10.1371/journal.pone.0318857
PMC ID: 11838866
SO-VID: 9f920419-3d87-427e-8aea-9034b5d7e2f1
Copyright © © 2025 Kominami et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 23K15929
Award Recipient
:
ORCID: https://orcid.org/0009-0000-0612-2576
Taro Kominami
Funded by:
funder-id http://dx.doi.org/10.13039/100019579, SingHealth;
Award ID: R1748/71/2020
Award Recipient
:
ORCID: https://orcid.org/0000-0002-5356-7604
Beau J. Fenner
Funded by:
funder-id http://dx.doi.org/10.13039/100019579, SingHealth;
Award ID: 05/FY2020/EX/06-A41
Award Recipient
:
Kanika Jain
Funded by:
funder-id http://dx.doi.org/10.13039/100019579, SingHealth;
Award ID: 05/FY2022/EX(SLP)/69-A131(b)
Award Recipient
:
Yasmin M. Bylstra
Funded by:
funder-id http://dx.doi.org/10.13039/100019579, SingHealth;
Award ID: 05/FY2022/EX(SLP)/69-A131(b)
Award Recipient
:
Weng Khong Lim
All the funding or resources of support for this study were the Japan Society for
the Promotion of Science (JSPS) KAKENHI, grant number 23K15929 to TK; the SingHealth
Foundation grant number R1748/71/2020 to BJF; and the SingHealth - Duke-NUS Institute
of Precision Medicine grant numbers 05/FY2020/EX/06-A41 and 05/FY2022/EX(SLP)/69-A131(b)
to KJ, YMB, and WKL. Funding organizations had no role in the design or conduct of
this study. There was no additional external funding received for this study.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Eye Diseases
Subject:
Retinal Disorders
Subject:
Retinitis
Subject:
Retinitis Pigmentosa
Subject:
Medicine and Health Sciences
Subject:
Ophthalmology
Subject:
Eye Diseases
Subject:
Retinal Disorders
Subject:
Retinitis
Subject:
Retinitis Pigmentosa
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Human Genetics
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Afferent Neurons
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Afferent Neurons
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Neuroscience
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Cognitive Science
Subject:
Cognitive Psychology
Subject:
Perception
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Sensory Perception
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Sensory Receptors
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Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Psychology
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Sensory Receptors
Subject:
Photoreceptors
Subject:
Social Sciences
Subject:
Psychology
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Sensory Receptors
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Sensory Perception
Subject:
Sensory Receptors
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Signal Transduction
Subject:
Sensory Receptors
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
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Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cognitive Science
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Vision
Subject:
Visual Acuity
Subject:
Biology and Life Sciences
Subject:
Psychology
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Vision
Subject:
Visual Acuity
Subject:
Social Sciences
Subject:
Psychology
Subject:
Cognitive Psychology
Subject:
Perception
Subject:
Sensory Perception
Subject:
Vision
Subject:
Visual Acuity
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Sensory Perception
Subject:
Vision
Subject:
Visual Acuity
Subject:
People and Places
Subject:
Geographical Locations
Subject:
Asia
Subject:
Singapore
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Regression Analysis
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