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      Discovery of virulence factors of pathogenic bacteria.

      Current Opinion in Chemical Biology
      Bacteria, genetics, metabolism, pathogenicity, Gene Expression Profiling, Genomics, Humans, Protein Processing, Post-Translational, Proteomics, Virulence Factors

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          Abstract

          Discovering virulence factors of pathogenic bacteria is a key in understanding pathogenesis and for identification of targets for novel drugs and design of new vaccines. Comparative genomics, transcriptomics, and proteomics have become the popular tools in discovering the virulence factors in bacterial pathogens, such as Neisseria meningitidis, Yersinia pestis, Mycobacterium tuberculosis, and Staphylococcus aureus. In addition, proteomics has been employed successfully in the study of the mechanism of post-translationally modified proteins of bacterial pathogens. Once the putative virulence factors are identified by genomics and/or proteomics, their functions and mechanisms can be further investigated by phenotypic analyses including mutagenesis and biochemical methods and/or structural biology. Combination of these techniques will accelerate the developments of therapeutic drugs and vaccines in combating bacterial diseases.

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          Author and article information

          Journal
          18284925
          10.1016/j.cbpa.2008.01.023

          Chemistry
          Bacteria,genetics,metabolism,pathogenicity,Gene Expression Profiling,Genomics,Humans,Protein Processing, Post-Translational,Proteomics,Virulence Factors

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