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      Gastrointestinale Endoskopie in Zeiten der COVID-19-Pandemie: Umsetzung von Empfehlungen und Erwartungen für die Zukunft Translated title: Challenges of the COVID-19 pandemic in gastrointestinal endoscopy: expectations and implementation of recommendations

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          Zusammenfassung

          Einleitung  Die COVID-19-Pandemie stellt die Gesundheitssysteme weltweit vor eine große Herausforderung. Aktuelle Daten deuten auf ein erhöhtes Risiko für eine SARS-CoV-2-Infektion für das Endoskopiepersonal hin. Für gastrointestinale Endoskopieeinheiten wurden mehrere Empfehlungen für die aktuelle Situation formuliert, jedoch liegen bislang keine Daten zur momentanen Versorgungsrealität vor.

          Material und Methodik  Vom 1. bis 7. April 2020 erfolgte eine deutschlandweite, webbasierte Umfrage unter den Mitgliedern der DGVS. Insgesamt wurden 33 Fragen gestellt, die auf Empfehlungen der ESGE (European Society of Gastrointestinal Endoscopy) basierten. Die Umfrage war an die Leiter von Endoskopieeinheiten gerichtet.

          Ergebnisse  Von 551 teilnehmenden Endoskopieeinheiten stornierten 37 % (202) weniger als 40 % ihrer Eingriffe. Kleinere Abteilungen (< 4000 Untersuchungen/Jahr) sagten einen signifikant geringeren Anteil ihrer Untersuchungen ab als größere (> 4000). Eine vollständige räumliche Trennung von Hochrisikopatienten war nur in 17 % der Fälle möglich. Prozedurale Maßnahmen wie strukturierte Risikostratifikation (91 %) oder Verwendung persönlicher Schutzausrüstung (PSA, 85 %) wurden meist umgesetzt. Für die Zukunft wurden Engpässe bei PSA (83 %) und Personal (69 %) sowie relevante finanzielle Verluste (80 %) erwartet.

          Schlussfolgerungen  Die Empfehlungen zu den strukturellen Maßnahmen waren nur eingeschränkt umsetzbar, und der Umfang von Stornierungen war heterogen. Eindeutige Definitionen notwendiger Endoskopien in der Pandemiesituation und eine Anpassung struktureller Gegebenheiten sowie eine finanzielle Absicherung erscheinen notwendig.

          Abstract

          Introduction  The COVID-19 pandemic represents a major challenge for health care systems worldwide. Recent data suggests an increased risk for personnel of gastrointestinal (GI) endoscopy units for SARS-CoV-2 infections. Several societies have provided recommendations for the current situation, but their feasibility is unclear and real-world data on preparedness of endoscopy units are lacking.

          Aims & Methods  A web-based survey among German GI-endoscopy heads was conducted from April 1 to April 7, 2020. It comprised 33 questions based on the ESGE (European Society of Gastrointestinal Endoscopy) recommendations and was distributed electronically by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS).

          Results  Of 551 completed surveys, 202 (37 %) endoscopy units cancelled less than 40 % of their procedures. Small-volume units (< 4000 procedures/year) cancelled significantly less procedures than high-volume units (> 4000). Complete spatial separation of high-risk patients was possible in only 17 %. Most units systematically identified patients at risk (91 %) and used risk adapted personal protective equipment (PPE, 85 %). For the future, shortages in PPE (83 %), staff (69 %) and relevant financial losses (80 %) were expected.

          Conclusions  Recommendations on structural measures were only partially fulfilled and cancellations of procedures were heterogeneous. Clear definitions of indications to perform endoscopies during such a pandemic are needed. Further, structural recommendations should be adapted and strategies to compensate financial losses need to be developed.

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          Most cited references14

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          Clinical Characteristics of Coronavirus Disease 2019 in China

          Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
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            Virological assessment of hospitalized patients with COVID-2019

            Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in late 20191,2. Initial outbreaks in China involved 13.8% of cases with severe courses, and 6.1% of cases with critical courses3. This severe presentation may result from the virus using a virus receptor that is expressed predominantly in the lung2,4; the same receptor tropism is thought to have determined the pathogenicity-but also aided in the control-of severe acute respiratory syndrome (SARS) in 20035. However, there are reports of cases of COVID-19 in which the patient shows mild upper respiratory tract symptoms, which suggests the potential for pre- or oligosymptomatic transmission6-8. There is an urgent need for information on virus replication, immunity and infectivity in specific sites of the body. Here we report a detailed virological analysis of nine cases of COVID-19 that provides proof of active virus replication in tissues of the upper respiratory tract. Pharyngeal virus shedding was very high during the first week of symptoms, with a peak at 7.11 × 108 RNA copies per throat swab on day 4. Infectious virus was readily isolated from samples derived from the throat or lung, but not from stool samples-in spite of high concentrations of virus RNA. Blood and urine samples never yielded virus. Active replication in the throat was confirmed by the presence of viral replicative RNA intermediates in the throat samples. We consistently detected sequence-distinct virus populations in throat and lung samples from one patient, proving independent replication. The shedding of viral RNA from sputum outlasted the end of symptoms. Seroconversion occurred after 7 days in 50% of patients (and by day 14 in all patients), but was not followed by a rapid decline in viral load. COVID-19 can present as a mild illness of the upper respiratory tract. The confirmation of active virus replication in the upper respiratory tract has implications for the containment of COVID-19.
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              Detection of SARS-CoV-2 in Different Types of Clinical Specimens

              This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.
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                Author and article information

                Journal
                Z Gastroenterol
                Z Gastroenterol
                10.1055/s-00000094
                Zeitschrift Fur Gastroenterologie
                Georg Thieme Verlag KG (Rüdigerstraße 14, 70469 Stuttgart, Germany )
                0044-2771
                1439-7803
                November 2020
                16 September 2020
                : 58
                : 11
                : 1074-1080
                Affiliations
                [1 ]Universitätsklinikum Halle, Klinik für Innere Medizin I, Halle, Germany
                [2 ]Universitätsklinikum Ulm, Klinik für Psychosomatische Medizin und Psychotherapie, Sektion Medizinische Psychologie, Ulm, Germany
                [3 ]Universitätsklinikum des Saarlandes, Klinik für Innere Medizin II, Homburg, Germany
                [4 ]Für die Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)
                Author notes
                Korrespondenzadresse Prof. Dr. med. Jonas Rosendahl Universitätsklinikum Halle (Saale) Klinik für Innere Medizin I Ernst-Grube-Str. 4006120 Halle (Saale)Deutschland+ 49/3 45/5 57 26 61 jonas.rosendahl@ 123456uk-halle.de
                Article
                10.1055/a-1246-3455
                7724582
                32937675
                aa4a8f34-b7ba-4aa3-be6b-7adc06fa7ed2
                Copyright @ 2020

                This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

                History
                : 15 June 2020
                : 19 August 2020
                Categories
                Originalarbeit

                covid-19,sars-cov-2,gastrointestinale endoskopie,persönliche schutzausrüstung,gastrointestinal endoscopy,personal protective equipment

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