Distribution Atlas of Proliferating Bone Marrow in Non-Small Cell Lung Cancer Patients Measured by FLT-PET/CT Imaging, With Potential Applicability in Radiation Therapy Planning.

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Abstract

Proliferating bone marrow is exquisitely sensitive to ionizing radiation. Knowledge of its distribution could improve radiation therapy planning to minimize unnecessary marrow exposure and avoid consequential prolonged myelosuppression. [18F]-Fluoro-3-deoxy-3-L-fluorothymidine (FLT)-positron emission tomography (PET) is a novel imaging modality that provides detailed quantitative images of proliferating tissues, including bone marrow. We used FLT-PET imaging in cancer patients to produce an atlas of marrow distribution with potential clinical utility.

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Journal

Journal ID (iso-abbrev): Int. J. Radiat. Oncol. Biol. Phys.

Title: International journal of radiation oncology, biology, physics

ISSN (Electronic): 1879-355X

ISSN (Print): 0360-3016

Publication date (Electronic): Aug 1 2015

Volume: 92

Issue: 5

Affiliations

[1 ] Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Australia. Electronic address: Belinda.Campbell@petermac.org.

[2 ] Centre for Molecular Imaging, Peter MacCallum Cancer Centre, East Melbourne, Australia.

[3 ] Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, East Melbourne, Australia.

[4 ] Radiotherapy Services, Peter MacCallum Cancer Centre, East Melbourne, Australia.

[5 ] Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, Australia.

[6 ] Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Australia.

Article

Publisher Item ID: S0360-3016(15)00427-7

DOI: 10.1016/j.ijrobp.2015.04.027

PubMed ID: 26194679

SO-VID: af88188a-b813-48dc-abb0-9392321913fc

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