This chapter critically evaluates the integration of Industry 4.0 technologies within the context of supply chain management (SCM), with a specific focus on examining its ethical and social implications. The research highlights the significant changes in workforce dynamics, the ethical considerations surrounding data-driven operations, and the importance of human-centered designs in the digital age, as they pertain to labor practices, data ethics, governance, and future prospects. This study employs a combination of literature reviews, case studies, and expert opinions to provide a comprehensive understanding of the importance of ethical considerations. These considerations encompass various aspects such as labor fairness, privacy, dilemmas related to artificial intelligence, and the integrity of data. Simultaneously, it brings attention to the societal consequences such as changes in employment patterns, the need for acquiring new skills, and the demand for inclusivity and fairness in the face of technological advancements.