Microbiologic and Histopathologic Features of Pedal Osteomyelitis

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The value of microbiology and histopathology in the diagnosis of neuropathic foot osteomyelitis remains poorly understood. In this retrospective cohort study, we evaluated the concordance of microbiology and histopathology results from bone resections and found similar proportions of bacterial growth in samples with and without histopathologic evidence of osteomyelitis.

Related collections

Most cited references 14

Record: found
Abstract: not found
Article: not found

The current burden of diabetic foot disease

Michael Edmonds, Chris Manu, Prashanth Vas (2021)

0 comments Cited 88 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis.

J R W Brownrigg, J Davey, P J Holt … (2012)

It is well established that diabetes mellitus increases the risk of cardiovascular disease (CVD) and all-cause mortality. Observational studies suggest that a history of diabetic foot ulceration (DFU) may increase this risk further still. We sought to determine to what extent DFU is associated with excess risk over and above diabetes. We identified studies reporting on associations of DFU with CVD and all-cause mortality. We obtained data on incident events of all-cause mortality, fatal myocardial infarction and fatal stroke. Study-specific estimates were pooled using a random-effects meta-analysis and the statistical heterogeneity of included studies was assessed using the I (2) statistic. The eight studies included reported on 3,619 events of all-cause mortality during 81,116 person-years of follow-up. DFU was associated with an increased risk of all-cause mortality (RR 1.89, 95% CI 1.60, 2.23), fatal myocardial infarction (2.22, 95% CI 1.09, 4.53) and fatal stroke (1.41, 95% CI 0.61, 3.24). CVD mortality accounted for a similar proportion of deaths in DFU and non-DFU patients. Patients with DFU have an excess risk of all-cause mortality, compared with patients with diabetes without a history of DFU. This risk is attributable, in part, to a greater burden of CVD. If this result is validated in other studies, strategies should evaluate the role of further aggressive CVD risk modification and ulcer prevention in those with DFU.

0 comments Cited 82 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures.

Eric Senneville, M Cazaubiel, Agnès M. Cordonnier … (2006)

We assessed the diagnostic value of swab cultures by comparing them with corresponding cultures of percutaneous bone biopsy specimens for patients with diabetic foot osteomyelitis. The medical charts of patients with foot osteomyelitis who underwent a surgical percutaneous bone biopsy between January 1996 and June 2004 in a single diabetic foot clinic were reviewed. Seventy-six patients with 81 episodes of foot osteomyelitis who had positive results of culture of bone biopsy specimens and who had received no antibiotic therapy for at least 4 weeks before biopsy constituted the study population. Pathogens isolated from bone samples were predominantly staphylococci (52%) and gram-negative bacilli (18.4%). The distributions of microorganisms in bone and swab cultures were similar, except for coagulase-negative staphylococci, which were more prevalent in bone samples (P < .001). The results for cultures of concomitant foot ulcer swabs were available for 69 of 76 patients. The results of bone and swab cultures were identical for 12 (17.4%) of 69 patients, and bone bacteria were isolated from the corresponding swab culture in 21 (30.4%) of 69 patients. The concordance between the results of cultures of swab and of bone biopsy specimens was 42.8% for Staphylococcus aureus, 28.5% for gram-negative bacilli, and 25.8% for streptococci. The overall concordance for all isolates was 22.5%. No adverse events--such as worsening peripheral vascular disease, fracture, or biopsy-induced bone infection--were observed, but 1 patient experienced an episode of acute Charcot osteoarthropathy 4 weeks after bone biopsy was performed. These results suggest that superficial swab cultures do not reliably identify bone bacteria. Percutaneous bone biopsy seems to be safe for patients with diabetic foot osteomyelitis.

0 comments Cited 67 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Julieta Madrid-Morales:

ORCID: https://orcid.org/0000-0002-3681-532X

Marissa M Maier:

ORCID: https://orcid.org/0000-0001-5505-1516

Amy Boda

Robert Bosch

Kristina L Bajema

Journal

Journal ID (nlm-ta): Open Forum Infect Dis

Journal ID (iso-abbrev): Open Forum Infect Dis

Journal ID (publisher-id): ofid

Title: Open Forum Infectious Diseases

Publisher: Oxford University Press (US )

ISSN (Electronic): 2328-8957

Publication date Collection: October 2024

Publication date (Electronic): 05 October 2024

Publication date PMC-release: 05 October 2024

Volume: 11

Issue: 10

Electronic Location Identifier: ofae592

Affiliations

Department of Medicine, Division of Infectious Disease, Oregon Health & Science University , Portland, Oregon, USA

Department of Medicine, Division of Infectious Disease, Veterans Affairs Portland Health Care System , Portland, Oregon, USA

Department of Medicine, Division of Infectious Disease, Oregon Health & Science University , Portland, Oregon, USA

Department of Medicine, Division of Infectious Disease, Veterans Affairs Portland Health Care System , Portland, Oregon, USA

Author notes

Correspondence: Julieta Madrid-Morales, MD, Department of Medicine, Division of Infectious Disease, Oregon Health and Science University, 3181 SW Sam Jackson Park Road L457, Portland, OR 97239-3098 ( julietamadrid1992@ 123456gmail.com ); Kristina L. Bajema, MD, MSc, Department of Medicine, Division of Infectious Disease, Veterans Affairs Portland Health Care System, Portland, OR ( Kristina.Bajema@ 123456va.gov ); Marissa M. Maier, MD, Department of Medicine, Division of Infectious Disease, Veterans Affairs Portland Health Care System, Portland, OR ( Marissa.Maier@ 123456va.gov ).

Potential conflicts of interest . All authors: No reported conflicts.

Author information

Julieta Madrid-Morales https://orcid.org/0000-0002-3681-532X

Marissa M Maier https://orcid.org/0000-0001-5505-1516

Article

Publisher ID: ofae592

DOI: 10.1093/ofid/ofae592

PMC ID: 11521324

PubMed ID: 39474450

SO-VID: ca923cf8-8e83-4832-bcc3-2f2b9b7c151d

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence ( https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

History

Date received : 27 July 2024

Date: 30 September 2024

Date accepted : 03 October 2024

Date: 29 October 2024

Page count

Pages: 3

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Most referenced authors 115

See all reference authors

Microbiologic and Histopathologic Features of Pedal Osteomyelitis

Read this article at

Abstract

Related collections

Microbiology Society

Most cited references 14

The current burden of diabetic foot disease

The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis.

Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures.

Author and article information

Contributors

Journal

Affiliations

Author notes

Author information

Article

History

Page count

Categories

Comments

Comment on this article

Similar content 247

Most referenced authors 115