Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B.

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Abstract

Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), a mini-chromosome essential for HBV replication, is supposed to be resistant to nucleos(t)ide analogue treatment. We investigated the effect of long-term nucleos(t)ide analogue treatment on cccDNA.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

Publisher: Elsevier BV

ISSN (Electronic): 1600-0641

ISSN (Print): 0168-8278

Publication date (Electronic): Feb 2017

Volume: 66

Issue: 2

Affiliations

[1 ] Department of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. Electronic address: hrmelcl@hku.hk.

[2 ] Department of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. Electronic address: dannykhwong@gmail.com.

[3 ] Department of Pathology, The University of Hong Kong, Hong Kong.

[4 ] Department of Medicine, The University of Hong Kong, Hong Kong.

[5 ] Department of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong.

[6 ] Johns Hopkins University School of Medicine, MD, USA.

[7 ] Department of Medicine, Columbia University Medical Campus, New York City, NY, USA.

Article

Publisher Item ID: S0168-8278(16)30487-1

DOI: 10.1016/j.jhep.2016.08.022

PubMed ID: 27639844

SO-VID: d1d80be9-2a6f-46ed-b62c-100bd196d5f2

History

Keywords: Antiviral therapy,Circular DNA,Hepatitis B virus,Liver biopsy,Virus replication

Data availability:

Keywords: Antiviral therapy, Circular DNA, Hepatitis B virus, Liver biopsy, Virus replication

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