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      Abnormal α‐synuclein deposits in skin nerves: intra‐ and inter‐laboratory reproducibility

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          Abstract

          Visualization of phosphorylated α-synuclein at serine 129 (p-syn) in skin nerves is a promising test for the in vivo diagnosis of synucleinopathies. Here the aim was to establish the intra- and inter-laboratory reproducibility of measurement of intraneural p-syn immunoreactivity in two laboratories with major expertise (Würzburg and Bologna).

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          A guide to the perplexed on the specificity of antibodies.

          Clifford B. Saper (2008)
          Many investigators are unaware of the potential problems with specificity of antibodies and the need to document antibody characterization meticulously for each antibody that is used. In this review, I consider the principles of antibody action and how they define a set of rules for what information should be obtained by the investigator before using an antibody in a serious scientific investigation.
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            Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder.

            Elena Antelmi, Vincenzo Donadio, Alex Incensi … (2017)
            To test if phosphorylated α-synuclein (p-α-syn) deposits can be detected by means of skin biopsy in patients with idiopathic REM sleep behavior disorder (iRBD) as a potential early histopathologic marker of impending synucleinopathy.
            Article 0 comments Cited 46 times – based on 0 reviews     Review now
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              Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy.

              Kathrin Doppler, Jessica Weis, Katharina Karl … (2015)
              MSA is characterized by deposition of alpha-synuclein (α-Syn) in oligodendrocytes and central nervous system (CNS) neurons. After recently detecting phospho-α-Syn (p-α-Syn) in dermal nerve fibers of patients with Parkinson's disease (PD), we assessed skin biopsies from patients with MSA to evaluate its potential role as a biomarker.
              Article 0 comments Cited 37 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: European Journal of Neurology
                Abbreviated Title: Eur J Neurol
                Publisher: Wiley
                ISSN (Print): 1351-5101
                ISSN (Electronic): 1468-1331
                Publication date Created: September 09 2019
                Publication date Created: October 2019
                Publication date (Electronic): August 02 2019
                Publication date (Print): October 2019
                Volume: 26
                Issue: 10
                Pages: 1245-1251
                Affiliations
                [1 ]IRCCS Istituto delle Scienze Neurologiche Bologna Italy
                [2 ]Department of Neurology University Hospital Würzburg WürzburgGermany
                [3 ]Philipps University Marburg Germany
                Article
                DOI: 10.1111/ene.13939
                PubMed ID: 30770596
                SO-VID: e7820cf4-e64c-4ef1-82c2-c4ac33737314
                Copyright © © 2019
                License:

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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