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      DeepDRiD: Diabetic Retinopathy—Grading and Image Quality Estimation Challenge

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          Summary

          We described a challenge named “Diabetic Retinopathy (DR)—Grading and Image Quality Estimation Challenge” in conjunction with ISBI 2020 to hold three sub-challenges and develop deep learning models for DR image assessment and grading. The scientific community responded positively to the challenge, with 34 submissions from 574 registrations. In the challenge, we provided the DeepDRiD dataset containing 2,000 regular DR images (500 patients) and 256 ultra-widefield images (128 patients), both having DR quality and grading annotations. We discussed details of the top 3 algorithms in each sub-challenges. The weighted kappa for DR grading ranged from 0.93 to 0.82, and the accuracy for image quality evaluation ranged from 0.70 to 0.65. The results showed that image quality assessment can be used as a further target for exploration. We also have released the DeepDRiD dataset on GitHub to help develop automatic systems and improve human judgment in DR screening and diagnosis.

          Graphical abstract

          Highlights

          • Provides the DeepDRiD dataset, performance evaluation, top methods and results

          • Presents deep learning approaches in DR image quality assessment and grading

          • Discusses the future work of DR automatic screening

          The bigger picture

          Diabetic retinopathy (DR) is the most common disease caused by diabetes. Challenges are held to address real-world issues encountered in the design of DR automated screening systems to advance the technology in this area. Thus, we described a challenge named "Diabetic Retinopathy (DR)—Grading and Image Quality Estimation Challenge" in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI 2020) for fundus image assessment and DR grading. The scientific community responded positively to the challenge. In the challenge, we provided a deep DR image dataset (DeepDRiD) containing regular DR images and ultra-widefield (UWF) DR images, both having image quality and DR grading diagnosis. We discussed details of the three best algorithms in each sub-challenges. The results by the top algorithms showed that image quality assessment can be used as a target for further exploration.

          Abstract

          In DeepDRiD challenge, organizers hold a real-world exploration in diabetic retinopathy (DR) auto-screening systems using regular fundus images from 500 participants and ultra-widefield fundus images from 128 participants. Among the 34 participating teams, we summarized the top 3 teams in the three sub-challenges involved in DR grading and image quality assessment. In addition to providing new insights into image quality assessment strategy, these models can enhance the judgment of healthcare workers in DR screening and bring precise screening results.

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          Most cited references43

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          Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.

          Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, removing the need to specify rules explicitly. Application of these methods to medical imaging requires further assessment and validation.
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            Very Deep Convolutional Networks for Large-Scale Image Recognition

            In this work we investigate the effect of the convolutional network depth on its accuracy in the large-scale image recognition setting. Our main contribution is a thorough evaluation of networks of increasing depth using an architecture with very small (3x3) convolution filters, which shows that a significant improvement on the prior-art configurations can be achieved by pushing the depth to 16-19 weight layers. These findings were the basis of our ImageNet Challenge 2014 submission, where our team secured the first and the second places in the localisation and classification tracks respectively. We also show that our representations generalise well to other datasets, where they achieve state-of-the-art results. We have made our two best-performing ConvNet models publicly available to facilitate further research on the use of deep visual representations in computer vision.
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              Squeeze-and-Excitation Networks

              The central building block of convolutional neural networks (CNNs) is the convolution operator, which enables networks to construct informative features by fusing both spatial and channel-wise information within local receptive fields at each layer. A broad range of prior research has investigated the spatial component of this relationship, seeking to strengthen the representational power of a CNN by enhancing the quality of spatial encodings throughout its feature hierarchy. In this work, we focus instead on the channel relationship and propose a novel architectural unit, which we term the "Squeeze-and-Excitation" (SE) block, that adaptively recalibrates channel-wise feature responses by explicitly modelling interdependencies between channels. We show that these blocks can be stacked together to form SENet architectures that generalise extremely effectively across different datasets. We further demonstrate that SE blocks bring significant improvements in performance for existing state-of-the-art CNNs at minimal additional computational cost. Squeeze-and-Excitation Networks formed the foundation of our ILSVRC 2017 classification submission which won first place and reduced the top-5 error to 2.251%, surpassing the winning entry of 2016 by a relative improvement of ∼25%. Models and code are available at https://github.com/hujie-frank/SENet.
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                Author and article information

                Contributors
                Journal
                Patterns (N Y)
                Patterns (N Y)
                Patterns
                Elsevier
                2666-3899
                20 May 2022
                10 June 2022
                20 May 2022
                : 3
                : 6
                : 100512
                Affiliations
                [1 ]Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, China
                [2 ]MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University, Shanghai, China
                [3 ]Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
                [4 ]Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
                [5 ]Department of Electromechanical Engineering, University of Macau, Macao, China
                [6 ]VUNO Inc., Korea
                [7 ]Department of Mathematics, City University of Hong Kong, Hong Kong, China
                [8 ]Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University, Shanghai, China
                [9 ]School of Electronic Information, Hangzhou Dianzi University, Hangzhou, China
                [10 ]Bournemouth University, United Kingdom
                [11 ]Healthcare Technology Innovation Centre, IIT Madras, India
                [12 ]School of Computer Science and Engineering, Beihang University, Beijing, China
                [13 ]Nanjing University of Science and Technology, Nanjing, China
                [14 ]Shri Guru Gobind Singhji Institute of Engineering and Technology, Nanded, India
                [15 ]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
                [16 ]Shanghai Zhi Tang Health Technology Co., LTD., China
                [17 ]Shanghai Key Laboratory of Computer Software Testing & Evaluating, Shanghai Development Center of Computer Software Technology, Shanghai, China
                [18 ]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
                [19 ]Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
                [20 ]School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
                [21 ]Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai, China
                [22 ]Department of Computer Science and Engineering, The Ohio State University, Ohio, USA
                [23 ]Department of Biomedical Informatics, The Ohio State University, Ohio, USA
                [24 ]Translational Data Analytics Institute, The Ohio State University, Ohio, USA
                Author notes
                []Corresponding author huarting99@ 123456sjtu.edu.cn
                [∗∗ ]Corresponding author dinggang.shen@ 123456gmail.com
                [∗∗∗ ]Corresponding author shengbin@ 123456sjtu.edu.cn
                [25]

                These authors contributed equally

                [26]

                Lead contact

                Article
                S2666-3899(22)00104-0 100512
                10.1016/j.patter.2022.100512
                9214346
                35755875
                e924edb7-7b36-457a-a1e9-852f74fb633d
                © 2022 The Author(s)

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 14 March 2022
                : 28 March 2022
                : 25 April 2022
                Categories
                Descriptor

                diabetic retinopathy,screening,deep learning,artificial intelligence,challenge,retinal image,image quality analysis,ultra-widefield,fundus image

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