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      A Digital Intervention for Adolescent Depression (MoodHwb): Mixed Methods Feasibility Evaluation

      research-article
      , PhD, MRCPsych 1 , 2 , 3 , , , PhD, FRCPsych 1 , 2 , , PhD 1 , 2 , , PhD 4 , , PhD 1 , 2 , 3 , , MD, FRCPsych 5 , , MD, FRANZP 6 , , PhD 7 , , MD, PhD, MRCGP 1 , 2 , , PhD, MRCPsych 1 , 2 , , PhD 8
      (Reviewer), (Reviewer)
      JMIR Mental Health
      JMIR Publications
      adolescent, depression, internet, education, early medical intervention, feasibility study

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          Abstract

          Background

          Treatment and prevention guidelines highlight the key role of health information and evidence-based psychosocial interventions for adolescent depression. Digital health technologies and psychoeducational interventions have been recommended to help engage young people and to provide accurate health information, enhance self-management skills, and promote social support. However, few digital psychoeducational interventions for adolescent depression have been robustly developed and evaluated in line with research guidance.

          Objective

          We aimed to evaluate the feasibility, acceptability, and potential impact of a theory-informed, co-designed digital intervention program, MoodHwb.

          Methods

          We used a mixed methods (quantitative and qualitative) approach to evaluate the program and the assessment process. Adolescents with or at elevated risk of depression and their parents and carers were recruited from mental health services, school counselors and nurses, and participants from a previous study. They completed a range of questionnaires before and after the program (related to the feasibility and acceptability of the program and evaluation process, and changes in mood, knowledge, attitudes, and behavior), and their Web usage was monitored. A subsample was also interviewed. A focus group was conducted with professionals from health, education, social, and youth services and charities. Interview and focus group transcripts were analyzed using thematic analysis with NVivo 10 (QSR International Pty Ltd).

          Results

          A total of 44 young people and 31 parents or carers were recruited, of which 36 (82%) young people and 21 (68%) parents or carers completed follow-up questionnaires. In all, 19 young people and 12 parents or carers were interviewed. Overall, 13 professionals from a range of disciplines participated in the focus group. The key themes from the interviews and groups related to the design features, sections and content, and integration and context of the program in the young person’s life. Overall, the participants found the intervention engaging, clear, user-friendly, and comprehensive, and stated that it could be integrated into existing services. Young people found the “Self help” section and “Mood monitor” particularly helpful. The findings provided initial support for the intervention program theory, for example, depression literacy improved after using the intervention (difference in mean literacy score: 1.7, 95% CI 0.8 to 2.6; P<.001 for young people; 1.3, 95% CI 0.4 to 2.2; P=.006 for parents and carers).

          Conclusions

          Findings from this early stage evaluation suggest that MoodHwb and the assessment process were feasible and acceptable, and that the intervention has the potential to be helpful for young people, families and carers as an early intervention program in health, education, social, and youth services and charities. A randomized controlled trial is needed to further evaluate the digital program.

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          Most cited references21

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          Effect of web-based depression literacy and cognitive-behavioural therapy interventions on stigmatising attitudes to depression: randomised controlled trial.

          Little is known about the efficacy of educational interventions for reducing the stigma associated with depression. To investigate the effects on stigma of two internet depression sites. A sample of 525 individuals with elevated scores on a depression assessment scale were randomly allocated to a depression information website (BluePages), a cognitive-behavioural skills training website (MoodGYM) or an attention control condition. Personal stigma (personal stigmatising attitudes to depression) and perceived stigma (perception of what most other people believe) were assessed before and after the intervention. Relative to the control, the internet sites significantly reduced personal stigma, although the effects were small. BluePages had no effect on perceived stigma and MoodGYM was associated with an increase in perceived stigma relative to the control. Changes in stigma were not mediated by changes in depression, depression literacy or cognitive-behavioural therapy literacy. The internet warrants further investigation as a means of delivering stigma reduction programmes for depression.
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            Persuasive Systems Design: Key Issues, Process Model, and System Features

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              The effectiveness of SPARX, a computerised self help intervention for adolescents seeking help for depression: randomised controlled non-inferiority trial

              Objective To evaluate whether a new computerised cognitive behavioural therapy intervention (SPARX, Smart, Positive, Active, Realistic, X-factor thoughts) could reduce depressive symptoms in help seeking adolescents as much or more than treatment as usual. Design Multicentre randomised controlled non-inferiority trial. Setting 24 primary healthcare sites in New Zealand (youth clinics, general practices, and school based counselling services). Participants 187 adolescents aged 12-19, seeking help for depressive symptoms, with no major risk of self harm and deemed in need of treatment by their primary healthcare clinicians: 94 were allocated to SPARX and 93 to treatment as usual. Interventions Computerised cognitive behavioural therapy (SPARX) comprising seven modules delivered over a period of between four and seven weeks, versus treatment as usual comprising primarily face to face counselling delivered by trained counsellors and clinical psychologists. Outcomes The primary outcome was the change in score on the children’s depression rating scale-revised. Secondary outcomes included response and remission on the children’s depression rating scale-revised, change scores on the Reynolds adolescent depression scale-second edition, the mood and feelings questionnaire, the Kazdin hopelessness scale for children, the Spence children’s anxiety scale, the paediatric quality of life enjoyment and satisfaction questionnaire, and overall satisfaction with treatment ratings. Results 94 participants were allocated to SPARX (mean age 15.6 years, 62.8% female) and 93 to treatment as usual (mean age 15.6 years, 68.8% female). 170 adolescents (91%, SPARX n=85, treatment as usual n=85) were assessed after intervention and 168 (90%, SPARX n=83, treatment as usual n=85) were assessed at the three month follow-up point. Per protocol analyses (n=143) showed that SPARX was not inferior to treatment as usual. Post-intervention, there was a mean reduction of 10.32 in SPARX and 7.59 in treatment as usual in raw scores on the children’s depression rating scale-revised (between group difference 2.73, 95% confidence interval −0.31 to 5.77; P=0.079). Remission rates were significantly higher in the SPARX arm (n=31, 43.7%) than in the treatment as usual arm (n=19, 26.4%) (difference 17.3%, 95% confidence interval 1.6% to 31.8%; P=0.030) and response rates did not differ significantly between the SPARX arm (66.2%, n=47) and treatment as usual arm (58.3%, n=42) (difference 7.9%, −7.9% to 24%; P=0.332). All secondary measures supported non-inferiority. Intention to treat analyses confirmed these findings. Improvements were maintained at follow-up. The frequency of adverse events classified as “possibly” or “probably” related to the intervention did not differ between groups (SPARX n=11; treatment as usual n=11). Conclusions SPARX is a potential alternative to usual care for adolescents presenting with depressive symptoms in primary care settings and could be used to address some of the unmet demand for treatment. Trial registration Australian New Zealand Clinical Trials ACTRN12609000249257.
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                Author and article information

                Contributors
                Journal
                JMIR Ment Health
                JMIR Ment Health
                JMH
                JMIR Mental Health
                JMIR Publications (Toronto, Canada )
                2368-7959
                July 2020
                17 July 2020
                : 7
                : 7
                : e14536
                Affiliations
                [1 ] Division of Psychological Medicine and Clinical Neurosciences Medical Research Council Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff, Wales United Kingdom
                [2 ] National Centre for Mental Health Cardiff University Cardiff, Wales United Kingdom
                [3 ] Cwm Taf Morgannwg University Health Board Wales United Kingdom
                [4 ] Population Health Sciences University of Bristol Bristol, England United Kingdom
                [5 ] Institute of Health and Wellbeing University of Glasgow Glasgow, Scotland United Kingdom
                [6 ] Faculty of Medical and Health Sciences School of Medicine University of Auckland Auckland New Zealand
                [7 ] Department for Health University of Bath Bath, England United Kingdom
                [8 ] Medical Research Council/Chief Scientist Office Social and Public Health Sciences Unit Institute of Health and Wellbeing University of Glasgow Glasgow, Scotland United Kingdom
                Author notes
                Corresponding Author: Rhys Bevan Jones bevanjonesr1@ 123456cardiff.ac.uk
                Author information
                https://orcid.org/0000-0001-8976-9825
                https://orcid.org/0000-0002-3689-737X
                https://orcid.org/0000-0002-9484-1729
                https://orcid.org/0000-0002-8132-6920
                https://orcid.org/0000-0001-9541-6786
                https://orcid.org/0000-0002-2267-1951
                https://orcid.org/0000-0002-8281-1573
                https://orcid.org/0000-0001-8046-0784
                https://orcid.org/0000-0002-4589-8833
                https://orcid.org/0000-0001-5821-5889
                https://orcid.org/0000-0002-6219-1768
                Article
                v7i7e14536
                10.2196/14536
                7395255
                32384053
                f6ea09d1-c752-4ef0-b8c2-0dd58b246399
                ©Rhys Bevan Jones, Anita Thapar, Frances Rice, Becky Mars, Sharifah Shameem Agha, Daniel Smith, Sally Merry, Paul Stallard, Ajay K Thapar, Ian Jones, Sharon A Simpson. Originally published in JMIR Mental Health (http://mental.jmir.org), 17.07.2020.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Mental Health, is properly cited. The complete bibliographic information, a link to the original publication on http://mental.jmir.org/, as well as this copyright and license information must be included.

                History
                : 25 August 2019
                : 22 October 2019
                : 17 December 2019
                : 2 February 2020
                Categories
                Original Paper
                Original Paper

                adolescent,depression,internet,education,early medical intervention,feasibility study

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