Intranasal octenidine for methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) carriers and universal octenidine bathing reduced MRSA acquisition in an acute-care general ward

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Abstract

In this quasi-experimental before-and-after study in a methicillin-resistant staphylococcus aureus (MRSA) high-prevalence acute-care dermatology ward from August 2016 to November 2018, patients admitted during intervention period who received additional topical intranasal octenidine were 63% less likely to acquire MRSA than those receiving universal daily octenidine bathing alone during baseline period (aOR, 0.37; 95% CI, 0.14–0.98).

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Most cited references 10

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Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

N.-O. Hübner, J Siebert, A. Kramer (2010)

Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and prospective controlled trials. Nowadays, octenidine is an established antiseptic in a large field of applications and represents an alternative to older substances such as chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current literature and unpublished original data as well.

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Staphylococcal decolonisation: an effective strategy for prevention of infection?

Andrew Simor (2011)

Staphylococcus aureus decolonisation--treatment to eradicate staphylococcal carriage--is often considered as a measure to prevent S aureus infection. The most common approach to decolonisation has been intranasal application of mupirocin either alone or in combination with antiseptic soaps or systemic antimicrobial agents. Some data support the use of decolonisation in surgical patients colonised with S aureus, particularly in those undergoing cardiothoracic procedures. Although this intervention has been associated with low rates of postoperative S aureus infection, whether overall rates of infection are also decreased is unclear. Patients undergoing chronic haemodialysis or peritoneal dialysis might benefit from decolonisation, although repeated courses of treatment are needed, and the effects are modest. Eradication of meticillin-resistant S aureus (MRSA) carriage has generally been difficult, and the role of decolonisation as an MRSA infection control measure is uncertain. The efficacy of decolonisation of patients with community-associated MRSA has not been established, and the routine use of decolonisation of non-surgical patients is not supported by data. Copyright © 2011 Elsevier Ltd. All rights reserved.

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Use of octenidine dihydrochloride in meticillin-resistant Staphylococcus aureus decolonisation regimens: a literature review.

B.V.S. Krishna, A.P. Gibb (2010)

Decolonisation of patients colonised with meticillin-resistant Staphylococcus aureus (MRSA) is one of the recommended methods for controlling MRSA in hospitals but there is a limited choice of agents that can be used. Octenidine dihydrochloride is a relatively new antiseptic that has been used for MRSA decolonisation in some countries. On reviewing available literature on its use for MRSA decolonisation, only four observational studies were found. All of these were small studies, which differed in study design. MRSA decolonisation rates of 6-75% have been reported. Patients with wound colonisation were included in these studies but it was not clear if the hair was treated in two of these. Octenidine appears to be as effective as chlorhexidine for MRSA decolonisation with fewer adverse effects, but large randomised trials incorporating octenidine as a skin disinfectant for MRSA decolonisation need to be undertaken to confirm its usefulness in clinical settings. Copyright 2009 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

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Author and article information

Contributors

Angela Chow: (View ORCID Profile)

Journal

Title: Infection Control & Hospital Epidemiology

Abbreviated Title: Infect. Control Hosp. Epidemiol.

Publisher: Cambridge University Press (CUP)

ISSN (Print): 0899-823X

ISSN (Electronic): 1559-6834

Publication date Created: November 2022

Publication date (Electronic): July 16 2021

Publication date (Print): November 2022

Volume: 43

Issue: 11

Pages: 1701-1704

Article

DOI: 10.1017/ice.2021.300

PubMed ID: 34266515

SO-VID: ff1136f1-c1bd-4fe5-8825-70ff2533c52c

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