This paper puts forward a syntactic account for the evolution of pragmatic expressions with a focus on sentence adverbs and modal particles. These go back to very different sources, ranging from adjectives or adverbs to focus particles to fully-fledged finite or non-finite clauses. The paper’s main aim is to identify the major characteristics and the driving force behind these developments.The proposal is built on recent synchronic approaches positing a syntactically encoded layer in sentential architecture which hosts projections related to evidential or epistemic speaker evaluation, to properties of the speech act and the like (e.g. Krifka 2023). It will be argued that it is this layer that propels pertinent diachronic processes of ‘pragmaticalization’ along different pathways. Based on Diewald’s (2011) notion of pragmaticalization as grammaticalization of discourse functions, pragmaticalization is defined syntactically as grammaticalization into this higher functional layer. This way, the key characteristics of the process and its differences to classical grammaticalization can be accounted for.

Ectomesenchymal chondromyxoid tumor (ECT) is a rare benign intraoral tumor that almost exclusively presents as a small mass on the anterior dorsal tongue. Recently, the ras-responsive element-binding protein 1::myocardin-related transcription factor B (RREB1::MRTFB; previously known as MKL2) fusion gene has been identified in 90% of ECTs, all localized to the tongue, highlighting its genetic distinctiveness. Herein, we report a mesenchymal tumor involving the plantar fascia of the left foot in a young woman, harboring the RREB1::MRTFB fusion gene.

To provide an overview of the predictive value of A Body Shape Index (ABSI) for the risk of cardiovascular events.

This study aimed to investigate the association between psoriasis and Life's Essential 8 (LE8), which has demonstrated an inverse relationship with various chronic diseases, though its link to psoriasis remains unexplored. In this cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) conducted during 2005 to 2006 and 2009 to 2014 that included participants who were 20 years or older. The LE8 score was calculated based on the American Heart Association's recommendations and categorized into three levels: low (0-49), moderate (50-79), and high (80-100). Psoriasis was identified using self-reported questionnaires. Weighted multivariable logistic regression and restricted cubic splines were applied to evaluate the relationship between LE8 scores and psoriasis. The study included 12,744 participants with an average age of 46.2 years (95% CI: 45.53-46.87 years); 6,289 (50.96%) were female, and 374 (2.9%) reported having psoriasis. The weighted mean LE8 score was 68.50 (95% CI: 67.94-69.07). After complete adjustment, a linear negative association was observed between psoriasis and the LE8 score (OR per 1 SD increase: 0.86, 95% CI: 0.75-0.99). Among the subscales, the health factors score showed a linear relationship with psoriasis, while a nonlinear relationship was found between psoriasis and the health behaviors score. Additionally, BMI, an LE8 component, demonstrated a significant association with psoriasis (OR per 1 SD increase: 0.84, 95% CI: 0.72-0.98) in multivariable logistic regression models. Subgroup and sensitivity analyses confirmed the robustness of these findings. We identified a linear negative relationship between psoriasis and LE8, demonstrating that improving LE8 management could serve as a potential strategy for preventing and managing psoriasis.