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      Current Issues and Technical Advances in Cultured Meat Production: A Review

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          Abstract

          As the global population grows, we need a stable protein supply to meet the demands. Although plant-derived protein sources are widely available, animal meat maintains its popularity as a high-quality and savory protein source. Recently, cultured meat, also known as in vitro meat, has been suggested as a meat analog produced through in vitro cell culture technology. Cultured meat has several advantages over conventional meat, such as environmental protection, disease prevention, and animal welfare. However, cultured meat manufacturing is an emerging technology; thus, its further and dynamic development would be pivotal. Commercialization of cultured meat to the public will take a long time but cultured meat undoubtedly will come to our table someday. Here, we discuss the social and economic aspects of cultured meat production as well as the recent technical advances in cultured meat technology.

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          Most cited references119

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          Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle.

          Aging skeletal muscles suffer a steady decline in mass and functional performance, and compromised muscle integrity as fibrotic invasions replace contractile tissue, accompanied by a characteristic loss in the fastest, most powerful muscle fibers. The same programmed deficits in muscle structure and function are found in numerous neurodegenerative syndromes and disease-related cachexia. We have generated a model of persistent, functional myocyte hypertrophy using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1). Transgenic embryos developed normally, and postnatal increases in muscle mass and strength were not accompanied by the additional pathological changes seen in other Igf-1 transgenic models. Expression of GATA-2, a transcription factor normally undetected in skeletal muscle, marked hypertrophic myocytes that escaped age-related muscle atrophy and retained the proliferative response to muscle injury characteristic of younger animals. The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty.
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            Scientific, sustainability and regulatory challenges of cultured meat

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              Environmental impacts of cultured meat production.

              Cultured meat (i.e., meat produced in vitro using tissue engineering techniques) is being developed as a potentially healthier and more efficient alternative to conventional meat. Life cycle assessment (LCA) research method was used for assessing environmental impacts of large-scale cultured meat production. Cyanobacteria hydrolysate was assumed to be used as the nutrient and energy source for muscle cell growth. The results showed that production of 1000 kg cultured meat requires 26-33 GJ energy, 367-521 m(3) water, 190-230 m(2) land, and emits 1900-2240 kg CO(2)-eq GHG emissions. In comparison to conventionally produced European meat, cultured meat involves approximately 7-45% lower energy use (only poultry has lower energy use), 78-96% lower GHG emissions, 99% lower land use, and 82-96% lower water use depending on the product compared. Despite high uncertainty, it is concluded that the overall environmental impacts of cultured meat production are substantially lower than those of conventionally produced meat.
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                Author and article information

                Journal
                Food Sci Anim Resour
                Food Sci Anim Resour
                Food Sci Anim Resour
                kosfa
                Food Science of Animal Resources
                Korean Society for Food Science of Animal Resources
                2636-0772
                2636-0780
                May 2021
                01 May 2021
                : 41
                : 3
                : 355-372
                Affiliations
                [1 ]Department of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, Konkuk University , Seoul 05029, Korea
                [2 ]Department of Food Science and Biotechnology of Animal Resources, Konkuk University , Seoul 05029, Korea
                Author notes
                [* ]Corresponding author : Jeong Tae Do, Department of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology, Konkuk University, Seoul 05029, Korea, Tel: +82-2-450-3673, Fax: +82-2-455-1044, E-mail: dojt@ 123456konkuk.ac.kr
                [* ]Corresponding author : Sung Gu Han, Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Korea, Tel: +82-2-450-0526, Fax: +82-2-4556-1044, E-mail: hansg@ 123456konkuk.ac.kr

                † These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-5237-2266
                https://orcid.org/0000-0003-2755-433X
                https://orcid.org/0000-0001-7677-5978
                https://orcid.org/0000-0001-6721-1441
                https://orcid.org/0000-0002-1485-861X
                Article
                kosfa-41-3-355
                10.5851/kosfa.2021.e14
                8112310
                34017947
                52b148c1-d115-4b9c-9ff8-03a9f0e55b99
                © Korean Society for Food Science of Animal Resources

                This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 29 October 2020
                : 12 March 2021
                : 22 March 2021
                Funding
                Funded by: CrossRef http://dx.doi.org/10.13039/501100003725, National Research Foundation of Korea;
                Award ID: 2016M3A9B6946835
                Award ID: 2020R1A2C3007562
                Categories
                Review
                Custom metadata
                2021-05-01

                cultured meat,in vitro meat,livestock farming,myogenic satellite cells,alternative protein sources

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